Congratulations to Dr. Guerriero on receiving funding from the Concern Foundation. The lab is grateful for the support and is excited to continue researching new ways to improve breast cancer therapy. Link to funding: https://www.concernfoundation.org/researchers-we-fund
The Guerriero lab would like to welcome Kelly Zheng to the team! Kelly has also been jointly appoint to the Laboratory of Systems Pharmacology where she will be working on projects involving CyCIF.
Focus on suppressive macrophages may boost effects of PARP inhibitors.
Mehta et al. Nature Cancer, 2021 BWH Press Release
Modulating the immune system as an anti-cancer strategy has shown great promise in some types of cancer, however there has been limited responses in breast cancer. While the main focus of immunotherapy has been on the adaptive immune system, namely…
This work demonstrates cross-talk between PARP inhibition and the tumor microenvironment related to STING/TBK1/IRF3 pathway activation in cancer cells that governs CD8+ T-cell recruitment and antitumor efficacy. The data provide insight into the mechanism of action of PARP inhibitors in BRCA-associated breast…
