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Drs. Shapiro And Guerriero Publish Key Findings On The Role Of PARP Inhibitors In TNBC

Drs. Shapiro and Guerriero Publish Key Findings on the Role of PARP Inhibitors in TNBC

This work demonstrates cross-talk between PARP inhibition and the tumor microenvironment related to STING/TBK1/IRF3 pathway activation in cancer cells that governs CD8+ T-cell recruitment and antitumor efficacy. The data provide insight into the mechanism of action of PARP inhibitors in BRCA-associated breast cancer.

Source: Cancer Discovery

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